The e-Learning for Strengthening Higher Education (e-SHE) program is a five-year initiative by Ethiopia’s Ministry of Education, implemented with Mastercard Foundation, Arizona State University’s EdPlus, and Shayashone, targeting 800,000 students across 50 public universities. In its first year, the Open edX platform supported over 250,000 active learners and helped train more than 23,000 instructors in online teaching methods. The platform was customized with Salesforce integration for data management, tailored front-end portals for each institution, and underpins seven multimedia production centers supporting content development. For a higher education system with limited prior online infrastructure, these are concrete early results in a long-term effort to improve quality, access, and resilience.